Content

Lesions of the skin and mucous membranes of a person often have a fungal etiology. Among the drugs used for such diseases, one can single out the frequently prescribed drug Clotrimazole - it is affordable, safe and effective.

Clotrimazole ointment for men

A large percentage of fungal diseases occur in lesions of the genital organs. Among men's problems, thrush (candidiasis balanitis) is distinguished. The disease is caused by fungi of the genus Candida. Thrush is transmitted sexually, the carrier of the disease is one of the partners - a man or a woman. Often, candidiasis is not accompanied by severe symptoms: sometimes dryness, burning and itching of the penis, pain during urination, discomfort during intercourse.

If you have these symptoms or if your partner is ill, you should consult a doctor for a consultation, because a neglected fungal disease can cause the development of prostatitis or chronic diseases of the genitourinary system. To treat candidiasis, doctors often prescribe clotrimazole for men.

Positive feedback during the treatment received the release form of the drug in the form of a cream - a positive effect is achieved so quickly, it is convenient to use it. Nuances:

Small doses of the drug quickly stop the development of the disease, further use of the drug leads to the death of the pathogen within a week.

1. For a complete recovery, the course of treatment can last up to three weeks.
2. To achieve a therapeutic effect, it is necessary to apply a thin layer of cream on the washed affected area two to three times a day.
3. The ointment is poorly absorbed, so it is recommended not to dress immediately after applying the drug.
4. During treatment, wear comfortable, breathable clothing made from natural fibers.

Candida fungi are always present in the body, but they begin to multiply rapidly and become the cause of inflammation when immunity is weakened, antibiotics are taken, therefore greater effect treatment is achieved along with strengthening drugs and diet. The patient is prescribed fermented milk food, dietary supplements, a diet is recommended that excludes sweet, spicy, spicy and fried foods.

Ointment Clotrimazole for women

Thrush or candidal vulvitis in women is accompanied by symptoms:

• itching, burning and swelling of the genital organs;
• mucous discharge yellowish or white, sometimes there are abundant liquid discharge or curdled flakes;
• bad smell.

In the treatment of thrush, Clotrimazole is used for women. The use of ointment for the treatment of candidiasis received positive feedback - it immediately eliminates unpleasant itching and burning. The ointment goes on sale with a nozzle that is convenient for douching. The cream is administered once a day for three days. In the chronic course of the disease, it is recommended to apply the cream three times a day for two weeks.

A prerequisite for recovery is the observance of the rules of personal intimate hygiene, the wearing of cotton underwear, the exclusion for the duration of the treatment of sexual activity and the simultaneous treatment of the sexual partner. The drug can be prescribed without the presence of characteristic signs of the disease for the sanitation of the birth canal for women in the last trimester of pregnancy.

Instructions for use of Clotrimazole ointment

An antifungal drug in the form of an ointment involves external and vaginal use. The aluminum tube with the medication has an outer package - a cardboard box. The preparation is accompanied by instructions for the use of Clotrimazole. You can buy this medicine at a pharmacy without a doctor's prescription, it can be stored for two years in a dry place without sunlight.

When Clotrimazole ointment is prescribed, the instruction with recommendations for use informs the consumer that it is necessary to apply the ointment in small portions (the dosage is 5 millimeters) on a clean, dry surface and rub it in with light circular movements. The duration and frequency of application of the cream is strictly individual for each person, the type of lesion and is determined when prescribing the drug by a doctor. According to the annotation, the ointment can be applied to the foci of inflammation:

• skin of the whole body;
• mucous membranes of the oral cavity, genital organs (the mucous membrane of the eyes is excluded).

The composition of the ointment Clotrimazole

The drug is made on the basis of vaseline (paraffin). The composition of Clotrimazole includes excipients:

• propylene glycol;
• polyethylene oxide;
• methyl parahydroxybenzoate or methyl paraben (nipagin).

The active substance of the drug comes from the imidazole group. The mechanism of the therapeutic action of the substance is based on the fact that it disrupts the synthesis of ergosterol in fungal cells. This leads to disruption of the structure and damage to cell membranes. Additionally, the substance interacts with fungal enzymes, promotes the formation and accumulation of hydrogen peroxide in cells, which destroys cells.

Indications for use of Clotrimazole ointment

The properties of the drug to have a destructive effect on pathogens of fungal and infectious diseases are used to treat various diseases. It suppresses the action of pathogens:

• mycoses (yeast, molds, dermatophytes);
• coccal infections (streptococci, staphylococci);
• trichomonas infections.

According to the instructions, there are indications for the use of Clotrimazole:

• candidal balanitis and vulvitis;
• stomatitis;
• trichophytosis (ringworm);
• paronychia (inflammation of the periungual roller);
• trichomoniasis;
• pitiriasis (pink lichen);
• psoriasis;
• erythema;
• erythrasma (bacterial lesion of the skin in places of folds);
• inflamed hemorrhoids.

Side effects of Clotrimazole ointment

The drug should be used with caution during lactation. The instructions for Clotrimazole ointment contain warnings - when using the cream for the first time, it is recommended to apply it to a small area and see the reaction. When applied, it is possible side effects ointment clotrimazole:

• at the site of application - irritation, allergic reaction (peeling, redness of the skin, urticaria, tingling, itching, burning, blistering);
• headache, indigestion:
• frequent urination - in the treatment of candidiasis of the genital organs.

Contraindications ointment Clotrimazole

If there are indications for the use of the drug and hypersensitivity to the active substance medicine cannot be applied. There are contraindications of Clotrimazole:

• during pregnancy in the first months;
• when using alcohol and antibiotics;
• child under 12;
• liver diseases;
• during menstruation in the case of vaginal administration.

The price of Clotrimazole ointment

Specify the cost of the drug in Moscow and the region in the table:

Analogues of ointment Clotrimazole

Other drugs are prescribed for the treatment of fungal diseases. There are analogues of Clotrimazole:

• Candide;
• Candibene;
• Kanesten;
• Canison;
• Amyclone;
• Antifungal;
• Lamisil.

Clotrimazole - a drug (cream), belongs to the pharmacological group of antifungal drugs for the treatment of skin diseases. The instructions for use highlight the following features:

• During pregnancy: with caution
• When breastfeeding: with caution

Package

Compound

Gel 1% contains clotrimazole at a concentration of 10 mg / g, propylene glycol, macrogol 400, carbomer, rectified from food raw materials ethanol 96%, glycerol, sage essential extract.

The composition of the cream 1%: clotrimazole at a concentration of 10 mg / g, cetostearyl and benzyl alcohols, polysorbate 60, synthetic spermaceti, octyldodecanol, sorbitan stearate, water.

The composition of the ointment 1%: clotrimazole at a concentration of 10 mg / g, polyethylene oxides 400 and 1500, propylene glycol, methylparaben, nipagin.

The composition of the solution 1%: clotrimazole at a concentration of 10 mg / ml (in terms of dry matter), polyethylene glycol 400, propylene glycol, ethanol 96%.

The composition of the suppositories: one suppository contains 100 mg of the active substance and the base in the amount necessary to obtain a suppository weighing 2 g. Clotrimazole suppositories contain semi-synthetic glycerides as the base.

Tablet composition: 100, 200 or 500 mg of clotrimazole, lactose monohydrate, potato starch, adipic acid, sodium bicarbonate, colloidal silicon dioxide, sodium lauryl sulfate.

Release form

• gel 1% (packaging 20 and 40 g);
• cream 1% (tubes 15, 20, 30 and 50 g);
• ointment 1% (tubes 15, 20, 30 and 40 g);
• solution 1% (vials 15 ml);
• vaginal suppositories 0.1 g (packing No. 6);
• vaginal tablets 0.1, 0.2 or 0.5 g (packaging No. 1, No. 3, No. 6; tablets are completed with an applicator).

Tablets and vaginal suppositories Clotrimazole have an ATC code different from other dosage forms of the drug - G01AF02.

Clotrimazole can also be produced in the form of granules, powder for external use, spray.

The drug is intended for local (including intravaginal) and external use, tablets for oral administration are not available.

pharmachologic effect

Antimycotic.

Pharmacodynamics and pharmacokinetics

Clotrimazole is an imidazole derivative.

In vitro it shows high activity against the most pathogenic fungi that can cause serious infectious complications, namely:

• dermatophytes (Microsporum sp., Epidermophyton floccosum, Trichophyton sp.);
• yeast-like fungi (Cryptococcus neoformans, Candida sp.);
• dimorphic fungi (Histoplasma capsulatum, Paracoccidicides brasiliensis, Coccidiodes immitis).

The mechanism of action of clotrimazole is based on its ability to block the synthesis of proteins, nucleic acids and ergosterol, which is necessary for the construction of cell membranes of fungi. As a result, the cell membranes of the fungi are damaged, and the cells die.

In low concentrations, clotrimazole acts fungistatically. If the dose exceeds 20 μg / ml, the drug has a fungicidal effect, and not only on proliferating cells.

When used in high doses, it helps to increase the concentration of hydrogen peroxide in the fungal cell to a toxic value and, as a result, the destruction of fungal cells

When applied topically, the drug is absorbed by the epidermis. The highest concentration of the substance is determined in the reticuloderm. It is also able to penetrate into the keratin of the nails.

Clotrimazole enters the systemic circulation in very small amounts. It is metabolized in the liver to inactive substances that are excreted from the body with feces and urine.

With intravaginal application, 5 to 10% of clotrimazole is absorbed. The absorbed substance is metabolized in the liver. Metabolic products are excreted in bile.

Indications for use: why ointment, cream, gel, suppositories and Clotrimazole tablets?

What helps Clotrimazole ointment, gel, cream and solution?

The drug is prescribed for the treatment of fungal infections of the skin, which are caused by molds and yeasts, dermatophytes and other pathogens sensitive to clotrimazole.

They are also used as remedies for lichen caused by Malassezia furfur and erythrasma (pathogen - Corynebacterium minutissimum).

Ointment, cream, gel and Clotrimazole solution help: from nail fungus (onychomycosis, fungal paronychia), trichophytosis, dermatophytosis, fungal erosion and diaper rash, candidiasis, microsporia, epidermophytosis, dermatomycosis, mycoses complicated by secondary pyoderma.

Indications for the use of ointment, gel, cream and solution are, among other things, infectious diseases, pathogens that are resistant to nystatin and a number of other antifungal agents.

The drug is not suitable for the treatment of pink lichen, since this disease is most likely of a viral or infectious-allergic origin, and may also be the body's response to a severe shock or breakdown. Clotrimazole is effective for fungal infections.

The use of Clotrimazole ointment, gel and cream with clotrimazole in gynecology is shown:

• for the treatment and prevention of thrush;
• for the prevention of repeated fungal infections of the female reproductive system, which develop with prolonged antibiotic treatment or against the background of immunodeficiency states.

Also, a solution, gel, cream and ointment in gynecology is used to sanitize the genital tract before delivery.

Candles - what are they from?

An indication for the use of vaginal suppositories is vaginal candidiasis and genital superinfections provoked by microorganisms sensitive to clotrimazole. The drug is prescribed for women and - after the onset of sexual activity - for teenage girls.

What are Clotrimazole tablets for?

Clotrimazole tablets are used to treat blastomycotic infections of the vulva and vagina. In particular, the drug is prescribed for vaginitis caused by fungi of the genus Candida (including diseases caused by strains resistant to nystatin), caused by other pathogens sensitive to clotrimazole, superinfections of the genital organs, for sanitation of the genital tract before delivery.

Contraindications

Contraindication: hypersensitivity.

Side effects

Allergic reactions.

When applied to the skin, the following side effects are possible:

• burning;
• edema;
• the appearance of blisters;
• erythema;
• skin irritation;
• tingling sensation
• peeling.

Topical application for urogenital mycoses may be accompanied by burning, itching, swelling and hyperemia of the mucosa, intercurrent cystitis, vaginal discharge, increased urination, pain during intercourse.

When applied topically with mycoses of the oral cavity, redness of the mucous membrane, tingling and burning sensation at the site of application of the drug, irritation may be noted.

Instructions for use Clotrimazole: Clotrimazole for women and men

Ointment Clotrimazole: instructions for use. How to apply Clotrimazole ointment for men?

Before applying Clotrimazole ointment (Acre or other manufacturers), the affected areas of the body are pre-washed with soapy water and dried thoroughly.

The drug is applied to the affected areas (capturing small areas of healthy skin around the lesion) with a thin layer from 1 to 3 rubles / day. and rub lightly.

For 1 treatment of an area the size of a palm, a 5-mm strip of ointment is sufficient.

Regardless of what pathogens caused the disease, treatment after the relief of subjective symptoms is recommended to continue for another 2 weeks.

With ringworm, the course of treatment lasts from 3 to 4, with erythrasma - from 2 to 4, with multi-colored lichen - from 1 to 3 weeks.

If there is no clinical improvement after 4 weeks of regular use of the drug, the patient is sent for a second microbiological study and the treatment regimen is reviewed.

The use of ointment for thrush in women allows you to block the spread of fungal cells and - when prescribing higher doses - ensures their complete destruction. For therapeutic purposes, Clotrimazole from thrush is used 2 rubles / day, rubbing the ointment into the affected areas of the perineum.

For men, the method of application for thrush and other fungal infections of the genital organs (candidiasis balanoposthitis, urogenital candidiasis) is the same as for women.

The ointment is applied to the foreskin and glans penis and gently rubbed into the skin and mucous membranes. Multiplicity of applications - 2 rubles / day.

The drug is poorly absorbed into the skin, and its active substance is characterized by the ability to gradually accumulate in the upper layer of the skin. Due to these properties, the high efficiency of Clotrimazole ointment for thrush in men and women is ensured.

Cream Clotrimazole: instructions for use

The cream is intended for topical use. With thrush and other fungal diseases, it is applied to the affected areas twice or thrice during the day and lightly rubbed.

The duration of the course depends on the indications for use and ranges from 1-2 (with candidal balanitis / vulvitis) to 3-4 weeks (with dermatomycosis).

To prevent recurrence of the disease, it is very important not to stop treatment for another 2 weeks after the subjective symptoms of the infection disappear. If there is no improvement after 4 weeks of therapy, the patient should consult a doctor.

Vaginal cream Clotrimazole is injected into the vagina in portions of 5 grams 1 p. / day. within 3 days.

Instructions for the solution

Before applying Clotrimazole, the skin should be washed with warm soapy water (especially between the fingers) and dried well. The treatment of the affected areas is carried out 2-3 rubles / day. The amount of solution should be sufficient for uniform application to the entire affected surface.

If the skin of the feet is affected, the solution of liquid Clotrimazole must be applied after each wash.

The solution is the most preferred dosage form for onychomycosis. This is due to the fact that it has the best penetrating properties.

In case of fungal lesions of the oral cavity, the affected areas of the mucosa are treated with a cotton swab or swab, on which drops are first applied (from 10 to 20 drops are enough to treat each ear). Multiplicity of procedures - 3-4 rubles / day.

After applying Clotrimazole for an hour, you should refrain from eating and drinking.

Clotrimazole drops are also effective for onomycosis caused by yeast fungi. Drops are introduced into the ear with the help of turundas: a twisted cotton flagellum is moistened in a solution and 3-4 rubles / day. lay for 5-10 minutes in the ear canal. Treatment lasts from 3 to 4 weeks.

Instructions for gel

A feature of this dosage form is that the gel is well distributed on the skin and is also well absorbed into it. This allows you to use the drug, including for the treatment of hard-to-reach areas of the body.

Intravaginally, the gel is applied in the same way as the cream with clotrimazole: 1 p. / day. 5 grams. The course of treatment is 3 days.

Clotrimazole vaginal tablets: instructions for use

In the absence of other prescriptions, Clotrimazole Akri tablets and drugs synonymous with them for thrush and other fungal infections of the genital organs are used:

• within 3 days, 1 tablet 2 rubles / day;
• within 6 days, 1 tablet 1 rub./day.

How to administer Clotrimazole vaginal tablets? Before administration, the tablet is removed from the package and moistened with chilled boiled water. The drug should be administered in the supine position with legs bent at the knees.

In order for the tablet to completely dissolve and clotrimazole to work, it is necessary humid environment(Otherwise, undissolved particles may spill out). Therefore, the tablet is inserted into the vagina as deeply as possible. It is optimal to carry out the procedure before going to bed.

Treatment must be stopped before the onset of menstruation. Menstrual flow will wash out the drug, and it will not have the desired effect. During treatment with vaginal tablets, tampons, spermicides, intravaginal douches and any other vaginal products should not be used.

For sanitation of the genital tract before delivery, a woman is given a single dose of 200 mg of clotrimazole.

During pregnancy, the drug is contraindicated in the 1st trimester. At a later date, clotrimazole does not adversely affect the development of the fetus, however, the use of the applicator may be associated with certain risks.

Instructions for candles

Candles from thrush are used intravaginally. The drug should be injected deep into the vagina, one daily for 6 days. Conducting a second course is possible after consulting a doctor.

Candles Clotrimazole with thrush and other urogenital mycoses is not used during menstrual bleeding. Treatment must be completed before it begins.

During pregnancy, the drug in this dosage form is used from the 2nd trimester and in situations where the expected benefit to the mother outweighs the possible risks to the fetus.

Reviews allow us to conclude that the drug quickly destroys fungal colonies and eliminates the unpleasant symptoms of fungal infections. Its other advantages include low price and a large selection of dosage forms.

Overdose

When applied to the skin and intravaginally, there is no risk of acute intoxication, since clotrimazole enters the systemic circulation in very small quantities.

In case of accidental ingestion of Clotrimazole, nausea, anorexia, vomiting, gastralgia, liver dysfunction are possible. In rare cases, pollakiuria, hallucinations, drowsiness, skin allergic reactions are noted.

In this case, the patient is prescribed enterosorbents and symptomatic treatment. Gastric lavage is performed in situations where a life-threatening dose was taken within the previous hour, as well as in the presence of visible symptoms of an overdose (nausea, dizziness, vomiting).

Interaction

When used simultaneously with polyene antibiotics (amphotericin B, natamycin, nystatin), the drugs mutually suppress each other's activity.

Terms of sale

Over the counter.

Storage conditions

Keep away from moisture and light. Storage temperature should not exceed 25°C. Freezing of the cream, gel, ointment or solution is not allowed.

Best before date

Suppositories, cream, solution, gel and vaginal tablets are valid for 3 years after the date of issue. The shelf life for the ointment is 2 years.

special instructions

Avoid swallowing and contact with eyes.

With mycoses, all affected areas of the body should be treated simultaneously.

The use of vaginal tablets, unless otherwise advised by a doctor, is contraindicated in the presence of any of the following symptoms:

• acyclic vaginal bleeding;
• bloody discharge or pathological bleeding from the vagina, uterine hemorrhages;
• dysuria;
• lower abdominal pain;
• open sores, blisters, or sores of the vagina or vulva;
• any unpleasant symptoms associated with the use of Clotrimazole (irritation, redness, burning, swelling, etc.);
• chills or fever with a temperature rise above 38 ° C;
• nausea and/or vomiting;
• vaginal discharge with an unpleasant odor;
• diarrhea;
• pain in the shoulder or back.

To prevent reinfection, treatment is prescribed simultaneously to both partners. The optimal dosage form for men is a cream.

With trichomoniasis, in addition to the drug, chemotherapeutic agents for systemic treatment (metronidazole orally) are prescribed.

What is better ointment or cream Clotrimazole?

The choice in favor of one or another dosage form is made depending on the indications. Clotrimazole ointment for women and men is prescribed for diseases that are accompanied by increased dryness and flaking of the skin.

As a rule, these are skin mycoses (trichophytosis, microsporia) caused by dermatophytes, athlete's groin, erythrasma, pityriasis versicolor, isolated cases of smooth skin candidiasis, mixed bacterial-fungal infections.

With weeping inflammatory processes, it is more advisable to use a cream that has a drying effect.

Analogues of Clotrimazole

Synonyms of dosage forms for external use: Clotrimazole-Acri, Amiclon, Imidil, Candibene, Candizol, Candide, Kanesten, Kanizon, Funginal, Funugitsip.

Vag analogues. tab.: Candide, Imidil, Candizol, Candibene, Funginal, Candid-B6, Canison, Fungicip.

Which is better: Candide or Clotrimazole?

Candide is synonymous with Clotrimazole. The basis of both drugs is the same substance, so there are no fundamental differences between them.

Clotrimazole or Pimafucin - which is better?

The main component of Pimafucin is the antimycotic antibiotic nitamycin. Sensitivity to the drug is shown mainly by molds and yeasts (including the genera Penicillium, Candida, Cephalosporium, Aspergillus and Fusarium).

Less sensitive to Pimafucin are Pseudoallescheria boydii and dermatophytes. That is, in situations where the cause of the disease is fungi of the genus Epidermophyton, Trichophyton or Microsporum, the choice should be made in favor of the drug Clotrimazole.

The use of Clotrimazole is less often accompanied by hypersensitivity reactions. In addition, it is less likely than Pimafucin to provoke an imbalance in the microflora of the genital organs.

Clotrimazole for children

There is no experience with the use of a solution, ointment, gel and cream 1% in children.

Tablets are used from the age of 12, subject to the onset of menarche in the patient.

Candles are not prescribed for children.

Clotrimazole during pregnancy and lactation

Cream, gel, ointment, solution, suppositories and vag. tablets during pregnancy can be used from the 2nd trimester.

Strictly controlled studies regarding the safety of use during pregnancy, in this regard, Clotrimazole is not prescribed in the 1st trimester.

Clinical studies on the effect of the drug on fertility in women have not been conducted, in experiments on animals, adverse effects have not been identified.

Clotrimazole tablets and suppositories during pregnancy (in the 2nd and 3rd trimesters) do not have a negative effect on the fetus, but the use of the applicator can be dangerous.

At breastfeeding the drug is used with caution, since it is not known whether it penetrates into milk.

Akrikhin HFC JSC

Country of origin

Russia

Product group

Dermatological preparations

Antifungal agent.

Release forms

• tuba 20.0 in ind/pack

Description of the dosage form

• ointment of white or almost white color with a slight specific odor.

Special conditions

If after 4 weeks from the start of treatment there is no clinical improvement, it is necessary to conduct a microbiological study to confirm the diagnosis and exclude another cause of the disease. If hypersensitivity or irritation develops when using the drug, treatment should be stopped and another therapy should be selected. It is not recommended to apply the drug to the skin in the eye area.

Compound

• 100 g of ointment contain: active substance - clotrimazole 1 g; excipients - castor oil, water-soluble methylcellulose, distilled monoglycerides, propylene glycol, emulsifier, nipagin, succinic acid, sodium benzoate, purified water.

Clotrimazole indications for use

• - fungal diseases of the skin, including skin folds and feet, caused by dermatophytes, yeast (Candida spp.), molds and other fungi and pathogens sensitive to clotrimazole: ringworm, dermatophytosis, trichophytosis, epidermophytosis, microsporia, candidiasis, interdigital fungal erosion, fungal paronychia;
• - mycoses complicated by secondary pyoderma, as part of complex therapy;
• - pityriasis versicolor, versicolor, erythrasma.

Clotrimazole contraindications

• Hypersensitivity to clotrimazole or excipients, pregnancy (I trimester), children under 2 years of age.
• Carefully:
• Lactation period, pregnancy (II and III trimester).

clotrimazole dosage

Clotrimazole side effects

• In rare cases, there are local allergic reactions (redness, burning, itching, tingling at the site of application of the drug).
• Use during pregnancy and lactation
• In clinical and experimental studies, it has not been established that the use of Clotrimazole-Acri® during pregnancy or during lactation has bad influence on the health of a woman or a fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.
• The application of Clotrimazole-Acri® directly to the mammary gland during breastfeeding is contraindicated.

Clotrimazole ointment is intended for the treatment of fungal infections. The tool has a detrimental effect on many types of pathogenic microorganisms. The effective element of the drug penetrates the cell membrane and stops the development of the disease.

Clotrimazole is used in the complex treatment of various infections of the skin caused by excessive reproduction of Corynebacterium minutissimum and Malasseria furfur.

Due easy way use, a large percentage of the active substance in the composition and good tolerance on the part of patients, Clotrimazole has found wide application in the treatment of fungal infections.

The active substance of the product is clotrimazole - 1 g of the product contains 10 mg (the account is kept on a dry matter of 100%). The composition of the ointment also includes additional substances:

• polyethylene glycol acetostraryl alcohol;
• propylene glycol;
• cetosteryl alcohol;
• polyethylene glycol 400;
• proxanol 268.

The ointment is almost transparent, with a homogeneous consistency and a specific smell.

Release form Clotrimazole

The ointment is produced in the form of an aluminum tube (30 g, 20 g) with bushes having an internal lacquer coating. The tube is packaged in paper packaging. A leaflet is attached to the product - an insert with instructions for use and storage conditions.

Clotrimazole is also available in the form of:

1. vaginal tablets. Parallelepiped-shaped tablets with slightly rounded corners. Contains 100 mg of active substance. Each blister contains 6 dragees.
2. Cream. The cream has White color and homogeneous consistency, intended for external use. The amount of the active element in this form is 10 mg per 1 g of the product. The cream is packaged in tubes of 30 g, 20 g. Vaginal cream (2%) is produced in tubes of 50 g.
3. Solution for external use. It has a soft texture like an emulsion. A solution (1%) is produced in ampoules of 15 or 30 ml. Has a white or slightly orange color.
4. Candles. Vaginal suppositories have a cylindrical shape. Color - white or with a yellow tinge.

The product must not be frozen. You can store 3 years from the date of issue, at a temperature of 25 degrees.

Action

Clotrimazole belongs to a number of antifungal drugs with a wide spectrum of action. The active component of the product is clotrimazole, which has a destructive effect on various pathogenic microorganisms (dermatophytes, yeasts and molds), including dimorphic fungi and actinomycetes of the genus Nocardia.

The agent has a fungistatic, and with respect to dermatophytes and fungi of the genus Candida - a fungicidal effect.

Due to the property of the active substance to be quickly absorbed into the skin, when using the product, the fastest possible effect on the causative agent of the disease occurs. The skin under the influence of the drug is cleansed, its surface is leveled, the normal functioning of the affected organs is restored.

The active substance is able to penetrate the tissues of the placenta and appear in the body of the fetus. Given this fact, use Clotrimazole ointment during pregnancy or if you suspect it should be used with caution, only with the permission of a doctor, in case of emergency.

When using Clotrimazole ointment in high concentrations on problem areas of the skin, an increase in the effectiveness of exposure is observed.

Excretion of the decay products of the drug occurs through the kidneys.

The effect on resistant strains is rarely recorded. Clotrimazole has antibacterial properties against certain gram-positive cocci and corynebacteria. At certain concentrations, it has a trichomonacid effect. The active substance of the agent blocks the synthesis of nucleic acids, proteins and ergosterol in fungal cells, thereby causing the death of pathogenic microorganisms.

According to clinical research It is stated that the drug practically does not have a systemic effect.

Indications for use

Clotrimazole ointment has an antifungal effect, also actively acting on other pathogens that are dangerous to health.

Clotrimazole ointment is used for:

1. Thrush in men and women (candidiasis balanitis and vulvitis);
2. Paronycheia (inflammation of the periungual roller);
3. stomatitis;
4. Combinations of infections of candidiasis and trichomoniasis;
5. Dermatophyte;
6. Skin infections on the trunk and in the inguinal zone;
7. Detection of a fungal disease of the outer ear;
8. Mycoses;
9. coccal infections;
10. Trichomonas;
11. Pitiriase;
12. Psoriasis;
13. Erytheme;
14. Erythrasma (bacterial lesion of the skin in the areas of folds);
15. Completed hemorrhoids.

Often the remedy is used to treat herpes zoster, pityriasis, ringworm and color deprivation. Fungi that cause infection are sensitive to the active substance of the drug and are quickly destroyed when used.

Clotrimazole is also used for severe pigmentation. Clotrimazole copes with both herpes and streptoderma.

Side effects

When applying Clotrimazole ointment, you need to apply it to a small area and check the reaction of the body. The following side effects occur:

In areas where the product is applied, irritations, allergic reactions are possible in the form of:

• peeling;
• skin redness;
• urticaria;
• tingling and itching;
• burning sensation;
• blister formation.

Headaches, gastrointestinal upset;

Frequent urination (in the treatment of genital candidiasis).

Contraindications

The main contraindication to the use of the drug is hypersensitivity to the components of the drug.

1. Pregnancy (first months);
2. Use of alcohol and antibiotics;
3. Under the age of 12;
4. Liver diseases;
5. Menstrual cycle in case of vaginal administration.

Interaction with other medicines

Clotrimazole ointment may reduce exposure to:

• Nystatin;
• Amphotericin;
• Natamycin.

A negative reaction when interacting with other medicines should not be expected, since the resorption capacity of clotrimazole is rather low.

Instructions for use

Clotrimazole ointment is intended for external use. Apply the product to the previously washed and dried problem area. It is allowed to clean the area of ​​application of the agent with a soap that has a neutral effect. Rub the ointment with massaging movements until completely absorbed. The usual rate is 3 times a day.

The duration of the course is determined by the severity of the disease and the localization of the infection.

With dermatoses, the average course duration is about 4 weeks. With pityriasis versicolor - 3 weeks. With a fungal infection of the skin of the lower extremities, therapy should be continued for another 15 days after the symptoms disappear.

When treating nail fungus, both the nail plate and the skin around the finger should be treated. During the treatment of a fungal infection of the lower extremities, you need to wear tights, socks, shoes made of natural material so that the skin can breathe freely. It is also very important to observe the rules of hygiene, frequent change of socks.

After the first manifestations of healing, experts advise continuing to use the ointment for another two weeks in order to strengthen the result.

It is necessary to treat a fungal infection with Clotrimazole ointment only in a full course, without interrupting treatment, even if acute symptoms recede.

If the next application of the ointment is missed, the treatment of the affected area should be carried out as soon as possible.

If a pronounced improvement in the condition of the skin after 4 months of using the product is not observed, you need to consult a dermatologist and introduce an adjustment to the therapeutic course of treatment.

Instructions for use Clotrimazole for men

The main percentage of diseases caused by a fungal infection are lesions of the genital organs. Among the male population, there is a problem in the form of thrush (candidiasis balanitis). The disease is caused by fungi of the genus Candida. The infection is transmitted sexually.

Symptoms of candidiasis are:

• burning sensation and itching on the genitals;
• pain during urination;
• discomfort during sexual intercourse;
• swelling, rash on the genitals;
• discharge with an unpleasant odor.

Clotrimazole ointment has been successfully used to treat such an infection. Already from small doses, the disease begins to recede, further use leads to the death of the pathogen in 7 days. During the treatment period, loose cotton underwear should be worn.

The ointment is used topically, 2 times a day in the morning and at bedtime. Apply the ointment to the head of the penis, the foreskin.

Special Instructions

Before you start using Clotrimazole ointment, you should carefully read the instructions, especially with the special instructions in it:

1. With a fungal infection of the skin of the mammary gland during lactation, the use of the drug is not allowed;
2. The use of ointment in the first and second trimester of pregnancy is allowed only on the recommendation of a doctor;
3. This drug should not be used to treat a fungal infection of the skin around the eyes;
4. Do not apply the product to the mucous membranes and eyes. If the drug accidentally gets into these areas, they should be washed off as quickly as possible with plenty of running water;
5. With the appearance of pronounced local side reactions, the use of the ointment should be discontinued;
6. After working with the drug, wash your hands with warm water and soap;
7. The drug does not affect the functions of the brain, does not have a systemic effect on the body.

Cases of overdose are not registered.

Analogues

Substitute means of Ointment Clotrimazole are:

• Candide;
• Imidil;
• Antifungol;
• Akrikhin ointment;
• Amyclone;
• Candibene.

Non-hormonal antimycotic antimicrobial drug.

Price from 35 rub.

Non-hormonal antimycotic antimicrobial drug.

Application- trichophytosis, skin candidiasis, epidermophytosis.

Analogues- Mikoderil, Candizol, Lotrimin. You can find out more about analogues, their prices, and whether they are substitutes at the end of this article.

Today we will talk about Clotrimazole ointment. What kind of remedy, how does it affect the body? What are the indications and contraindications? How and in what doses is it used? What can be replaced?

What kind of ointment

Clotrimazole ointment is used in the presence of fungal diseases and is used for therapy, the purpose of which is the complete destruction of the cause of the infection.

In some cases, the ointment helps to get rid of erythrasma pathogens and, but only on early stage when the fungus affects small areas of the body.

The drug also fights the following symptoms:

• abrasions;
• peeling of the skin.

A distinctive feature is the possibility of use in case of infection of the vaginal area.

In addition to the ointment form, the medication is available in the form of a cream, gel, vaginal suppositories, solution, powder.

Estimated price (at the time of publication of the article):

• cream - from 28 rubles;
• ointment - from 35 rubles;
• gel - from 34 rubles;
• vaginal suppositories - from 55 rubles;
• solution - from 226 rubles;
• powder - from 37 rubles.

Active substance

The active substance of the drug is a derivative of imidazole, which fights the growth of a fungal infection. That is, it destroys the building material through which the disease spreads.

The active substance is universal, so Clotrimazole ointment is used to get rid of:

• dermatophytes;
• mold fungi;
• mushroom Candida.

In other cases, treatment may not be effective, so you should first consult with a dermatologist or therapist.

Release form, composition and packaging

The medicine is available in the form:

• 1% topical ointment;
• creams for topical and vaginal application;
• powder;
• solution;
• special vaginal suppositories;
• gel.

Depending on the stage of development of the fungal infection and the lesion, doctors recommend various forms of release that will be the most effective and safe.

Compound

The composition of the ointment is (10 mg per gram of the drug), while adding:

• propylene glycol;
• macrogol 400;
• carbomer;
• food ethyl alcohol content of 96%;
• glycerol;
• additional extracts for smell.

For different forms release, distinctive substances are added, such as: water, nipagin, glycerides, but they do not have any medicinal effect.

Package

The pharmaceutical company produces the following types of products:

• ointment (15, 20, 30 or 40 g);
• solution (vials of 15 ml);
• cream (15, 20, 30 or 50 g);
• vaginal suppositories, 0.1 g each;
• tablets (0.1 or 0.5 g).

pharmachologic effect

Affects the skin. medical result It is obtained due to a violation of the synthesis of the substance ergosterol, which is a building material for fungi.

At the same time, the drug is quite resistant to external environment and can act even in areas of high acidity. Often Clotrimazole is used in gynecology.

Indications for use

The main indication for the use of Clotrimazole ointment is the presence of a fungal infection. However, in most cases, it is quite difficult to notice it, so if symptoms occur, the doctor may prescribe a drug for preventive purposes.

• nail fungus;
• erosion caused by fungus;
• mycosis;

In some cases, doctors prescribe it if there is another infectious disease, but only if it is effective.

In the case of non-fungal infections, the effect of the drug will not have visible changes.

It is worth noting that the result of therapy depends on the amount of applied (or applied) medication.

1 At low dosages, the drug fights the further growth of harmful cells, temporarily stops their growth.

2 At dosages of 25 mcg / ml, the drug kills the fungus, while small pigment spots may appear on the skin as a result of the fight against the disease.

3 Doses above should only be used on specialist advice. Since at higher doses, the level of hydrogen in the cells of the fungus greatly increases. The fungus dies, but it harms the skin. If the focus of the fungal infection is too sensitive, then this can damage the body.

The ointment is absorbed by the top layer of the skin and subsequently excreted by the liver, and the remnants of the active substance are removed along with waste products.

For children

The drug is not toxic and the only contraindication to the use of Clotrimazole is the presence of an allergic reaction to any substance that is part of the drug. In other cases, dosages and methods of application do not differ from the course of treatment for adults.

For pregnant and lactating women

During pregnancy, the girl's body wears out and a very common result is the development of thrush.

Clotrimazole is safe for the unborn fetus, so this ointment can be used. To do this, you need a tampon, on the tip of which a small amount of medicine is squeezed out and inserted into the vagina.

It should not be used in the first months of pregnancy, since the active substance penetrates into milk in small quantities and at the stage of embryonic development there is a possibility of undesirable consequences.

Contraindications

The drug is not prescribed in the presence of an allergy to at least one substance from the composition or in case of hypersensitivity. The action of the drug is accompanied by an increase in temperature in the area of ​​\u200b\u200bthe body.

Other contraindications for use are:

• the gestation period is less than 3 months;
• individual intolerance;
• pathology of the hematopoietic organs;
• chronic liver diseases (must be observed by a doctor when using the drug).

How to use clotrimazole ointment

Each form of release has individual characteristics that must be considered in the course of treatment for fungal infections. Instructions for use of Clotrimazole ointment are quite simple.

For adults

1 Ointment, cream. A small amount of the contents (15-20 mcg) of the tube is squeezed onto the hand, after which it is rubbed into the lesion of a fungal infection. It is necessary to allow the substance to be absorbed. Apply to clean and dry skin. The procedure should be performed 3 times a day (preferably in the morning, afternoon and evening)

2 Solution. No need to dilute with water! About 25 ml of the solution is applied to the swab, after which it is rubbed into clean skin in the area affected by the infection. At the same time, if there are visible traces of the fungus, they should be removed with scissors or a file.

3 Candles. Introduced at bedtime, the woman should be in a prone position with her legs bent at the knees. The course of treatment is 6 days, one tablet per day, repeated therapy is prescribed only on the recommendation of the attending physician.

For children

Methods of application and dosage do not differ, however, a pediatrician may establish lower ones due to the individual characteristics of the organism.

During pregnancy and lactation

Should be used with caution. Clinical trials have shown no harm to the fetus, but it is worth delaying the treatment of a fungal infection until the baby is born.

In the case of thrush, treatment is prescribed strictly after the third month of pregnancy.

In violation of liver function

The ointment does not have high toxicity, but is excreted through the liver. Doctors rarely prescribe this kind of drugs for people with problems of this organ, but with constant supervision by a specialist, this is acceptable.

It is strictly not recommended to use ointment and other forms of release without the permission of the attending physician.

Side effects

The main side effects in the area of ​​application of the drug:

• burning;
• edema;
• blistering.

In some cases, it is possible:

• other skin diseases.

Sometimes with an increased treatment time, you notice:

• temperature increase;
• constant;
• decreased mood, short-term apathy.

When using tablets or suppositories, there may be:

• additional discharge from the vaginal area;
• gastralgia.

Serious violations in the functioning of the body were not identified.

special instructions

During the course of treatment with ointments, hygiene should be observed; when applied to dirty skin, part of the substance may not be absorbed and evaporate. The following guidelines must also be observed.

1 Before use, wash the affected area, wipe it thoroughly (without effort), if desired, apply a moisturizer. The skin should be clean and dry with a neutral ph environment (preferably).